SCHEMBL29153234

SCHEMBL29153234

Cc1ccc(Cl)c2[nH]c(=O)ccc12

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.59
CA12 O43570 1/20 0.47
CA9 Q16790 1/20 0.47
KDM4E B2RXH2 2/20 0.42
ALDH1A1 P00352 1/20 0.42
GLA P06280 1/20 0.42
GAA P10253 1/20 0.42
HPGD P15428 1/20 0.42
HSD17B10 Q99714 1/20 0.42
TP53 P04637 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
NQO2 P16083 3/20 0.39
CYP19A1 P11511 1/20 0.39
ADORA1 P30542 1/20 0.38
LMNA P02545 1/20 0.37
PDE3B Q13370 1/20 0.37
PDE3A Q14432 1/20 0.37
CES1 P23141 1/20 0.37
TNKS2 Q9H2K2 2/20 0.36
ADRA2A P08913 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25095885 0.85 MAPT (0.54) MAPTCA12CA9KDM4EALDH1A1
SCHEMBL2611661 0.84 KDM4E (0.47) MAPTKDM4EALDH1A1GLAGAA
SCHEMBL30023033 0.84 CA12 (0.53) MAPTCA12CA9KDM4EALDH1A1
SCHEMBL29153228 0.84 CA12 (0.53) MAPTCA12CA9KDM4EALDH1A1
SCHEMBL17542650 0.77 CA12 (0.47) MAPTCA12CA9KDM4EGAA
SCHEMBL12559617 0.77 CA12 (0.47) MAPTCA12CA9KDM4EALDH1A1
SCHEMBL30437983 0.77 CA12 (0.47) MAPTCA12CA9KDM4EALDH1A1
SCHEMBL9909522 0.77 DRD2 (0.53) MAPTKDM4EALDH1A1GLAGAA
SCHEMBL29153226 0.77 NQO2 (0.46) MAPTCA12CA9KDM4EHPGD
SCHEMBL8038912 0.74

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117222639-A Quinoline amine compound, preparation method and medical application thereof 江苏恒瑞医药股份有限公司 2023-12-12 CN disclosed