Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Obefazimod. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 2/20 | 0.53 |
| ▸ | CTSC | P53634 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | BCR | P11274 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | XPO1 | O14980 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Obefazimod SCHEMBL30729382 | 1.00 | DHFR (0.53) | DHFRCTSCKCNH2SCN5ASCN9A | |
| Obefazimod SCHEMBL1705888 | 0.99 | DHFR (0.54) | DHFRCTSCKCNH2SCN5ASCN9A | |
| Obefazimod SCHEMBL29077795 | 0.91 | ABL1 (0.50) | DHFRCTSCKCNH2SCN5ASCN9A | |
| Obefazimod SCHEMBL29077812 | 0.90 | DHFR (0.47) | DHFRCTSCCHRNA7SMN1; SMN2HTT | |
| Obefazimod SCHEMBL30116324 | 0.90 | DHFR (0.47) | DHFRCTSCCHRNA7SMN1; SMN2HTT | |
| SCHEMBL1702145 | 0.86 | CTSC (0.51) | DHFRCTSCCHRNA7 | |
| SCHEMBL19380740 | 0.84 | DHFR (0.55) | DHFRCTSCKCNH2SCN5ASCN9A | |
| SCHEMBL1706290 | 0.84 | DHFR (0.55) | DHFRCTSCKCNH2SCN5ASCN9A | |
| SCHEMBL1702468 | 0.83 | DHFR (0.58) | DHFRKCNH2SCN5ASCN9ACHRNA7 | |
| SCHEMBL1705361 | 0.83 | DHFR (0.54) | DHFRCTSCKCNH2SCN5ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117377658-A | Process for preparing quinoline derivative compounds | ABIVAX公司 | 2024-01-09 | — | — | CN | disclosed |