Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 14/20 | 0.92 |
| ▸ | EML4 | Q9HC35 | 13/20 | 0.92 |
| ▸ | ALK | Q9UM73 | 13/20 | 0.92 |
| ▸ | RET | P07949 | 12/20 | 0.92 |
| ▸ | ROS1 | P08922 | 12/20 | 0.92 |
| ▸ | AXL | P30530 | 2/20 | 0.92 |
| ▸ | ETV6 | P41212 | 2/20 | 0.92 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.92 |
| ▸ | PLK4 | O00444 | 1/20 | 0.92 |
| ▸ | CIT | O14578 | 1/20 | 0.92 |
| ▸ | AURKA | O14965 | 1/20 | 0.92 |
| ▸ | GAK | O14976 | 1/20 | 0.92 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.92 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.92 |
| ▸ | BUB1 | O43683 | 1/20 | 0.92 |
| ▸ | SNRNP200 | O75643 | 1/20 | 0.92 |
| ▸ | STK16 | O75716 | 1/20 | 0.92 |
| ▸ | STK10 | O94804 | 1/20 | 0.92 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.92 |
| ▸ | LATS1 | O95835 | 1/20 | 0.92 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gilteritinib SCHEMBL29355822 | 0.96 | FLT3 (1.00) | FLT3EML4ALKRETROS1 | |
| Gilteritinib SCHEMBL29432551 | 0.96 | FLT3 (1.00) | FLT3EML4ALKRETROS1 | |
| Gilteritinib SCHEMBL282229 | 0.96 | FLT3 (1.00) | FLT3EML4ALKRETROS1 | |
| SCHEMBL328303 | 0.93 | FLT3 (0.94) | FLT3EML4ALKRETROS1 | |
| Gilteritinib SCHEMBL29357951 | 0.92 | FLT3 (1.00) | FLT3EML4ALKRETROS1 | |
| Gilteritinib SCHEMBL21819929 | 0.92 | FLT3 (1.00) | FLT3EML4ALKRETROS1 | |
| Gilteritinib SCHEMBL22684910 | 0.91 | FLT3 (0.91) | FLT3EML4ALKRETROS1 | |
| Gilteritinib SCHEMBL22684912 | 0.91 | FLT3 (0.91) | FLT3EML4ALKRETROS1 | |
| SCHEMBL21455071 | 0.90 | FLT3 (0.89) | FLT3EML4ALKRETROS1 | |
| SCHEMBL22652336 | 0.90 | FLT3 (0.89) | FLT3EML4ALKRETROS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118021814-A | Combination therapy with EHMT2 inhibitors | EPIZYME股份有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-110621316-B | Combination therapy with EHMT2 inhibitors | EPIZYME股份有限公司 | 2024-01-26 | — | — | CN | disclosed |