Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 4/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30843868 | 1.00 | NAMPT (0.40) | NAMPTNPSR1ALDH1A1GAASYK | |
| SCHEMBL31554405 | 0.87 | ALDH1A1 (0.46) | NAMPTALDH1A1GAASYKRORC | |
| SCHEMBL14923668 | 0.85 | SYK (0.42) | NAMPTSYKRORCCYP17A1RAF1 | |
| SCHEMBL26967916 | 0.83 | NPSR1 (0.40) | NPSR1ALDH1A1BRAFEGFRSGMS2 | |
| SCHEMBL14923559 | 0.81 | SYK (0.46) | NAMPTSYKRORCCYP17A1AR | |
| SCHEMBL24343932 | 0.78 | NAMPT (0.41) | NAMPTALDH1A1GAASYKRORC | |
| SCHEMBL29534521 | 0.78 | NAMPT (0.41) | NAMPTALDH1A1GAASYKRORC | |
| SCHEMBL29157688 | 0.78 | BRD4 (0.37) | ALDH1A1BRD4EGFRAAK1KDM4E | |
| SCHEMBL30843850 | 0.78 | BRD4 (0.37) | ALDH1A1BRD4EGFRAAK1KDM4E | |
| SCHEMBL23147651 | 0.76 | ALDH1A1 (0.43) | NAMPTALDH1A1GAASYKRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4294804-B1 | PYRIDONE COMPOUNDS AND METHODS OF USE | EXELIXIS INC (US) | 2026-04-08 | — | — | EP | disclosed |
| CN-117440951-A | Pyridone compounds and methods of use | 埃克塞里艾克西斯公司 | 2024-01-23 | — | — | CN | disclosed |
| EP-4294804-A1 | PYRIDONE COMPOUNDS AND METHODS OF USE | Exelixis, Inc. (US) | 2023-12-27 | — | — | EP | disclosed |
| WO-2022178205-A1 | PYRIDONE COMPOUNDS AND METHODS OF USE | EXELIXIS, INC. (US) | 2022-08-25 | — | — | WO | disclosed |