⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12908061 | 0.82 | AR (0.41) | — | |
| SCHEMBL7529351 | 0.81 | DHFR (0.34) | — | |
| SCHEMBL11574020 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL5485232 | 0.73 | TSHR (0.41) | — | |
| SCHEMBL12789152 | 0.73 | TSHR (0.50) | — | |
| SCHEMBL28129975 | 0.71 | TSHR (0.61) | — | |
| SCHEMBL28140 | 0.71 | — | — | |
| SCHEMBL1641881 | 0.70 | — | — | |
| SCHEMBL12091672 | 0.70 | — | — | |
| SCHEMBL2921977 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| CN-113923988-A | Substituted arylmethyl and heteroarylmethyl ureas, analogs thereof, and methods of using the same | 爱彼特生物制药公司 | 2022-01-11 | — | — | CN | disclosed |
| US-9987277-B2 | Carboxamide 4-[(4-pyridyl)amino] pryimidines for the treatment of hepatitis C | JANSSEN SCIENCES IRELAND UC (IE) | 2018-06-05 | — | — | US | disclosed |
| US-9580411-B2 | Substituted sulfonamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2017-02-28 | — | — | US | disclosed |
| US-20150197509-A1 | SUBSTITUTED SULFONAMIDE SOLUTIONS | GENENTECH, INC. (US) | 2015-07-16 | — | — | US | disclosed |
| US-7829584-B2 | Pyridines and pyridine N-oxides as modulators of thrombin | JANSSEN PHARMACEUTICA NV (BE) | 2010-11-09 | — | — | US | disclosed |
| EP-1901748-B1 | ANGIOGENESIS INHIBITORS | ONCALIS AG (CH) | 2010-09-08 | — | — | EP | disclosed |
| WO-2010083617-A1 | PYRAZOLOPYRIMIDINES AS PROTEIN KINASE INHIBITORS | ONCALIS AG (CH) | 2010-07-29 | — | — | WO | disclosed |
| EP-1765351-B9 | PROTEIN KINASE INHIBITORS | ONCALIS AG (CH) | 2010-03-24 | — | — | EP | disclosed |
| US-20090247523-A1 | CARBOXAMIDE 4-[(4-PYRIDYL)AMINO]PYRIMIDINES USEFUL AS HCV INHIBITORS | JANSSEN SCIENCES IRELAND UC (IE) | 2009-10-01 | — | — | US | disclosed |
| EP-1765351-B1 | PROTEIN KINASE INHIBITORS | ONCALIS AG (CH) | 2009-03-04 | — | — | EP | disclosed |
| EP-1901748-A1 | ANGIOGENESIS INHIBITORS | Oncalis AG (CH) | 2008-03-26 | — | — | EP | disclosed |
| US-20070225282-A1 | PYRIDINES AND PYRIDINE N-OXIDES AS MODULATORS OF THROMBIN | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-09-27 | — | — | US | disclosed |
| US-20070149535-A1 | Protein kinase inhibitors | ONCALIS AG (CH) | 2007-06-28 | — | — | US | disclosed |
| EP-1765351-A1 | PROTEIN KINASE INHIBITORS | Oncalis AG (CH) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006131003-A1 | ANGIOGENESIS INHIBITORS | ONCALIS AG (CH) | 2006-12-14 | — | — | WO | disclosed |
| WO-2005120513-A1 | PROTEIN KINASE INHIBITORS | ONCALIS AG (CH) | 2005-12-22 | — | — | WO | disclosed |
| US-5342903-A | Process for the preparation of adducts of epoxides and alcohols | CIBA-GEIGY CORPORATION (US) | 1994-08-30 | — | — | US | disclosed |
| EP-0569331-A2 | Process for the preparation of addition products | CIBA-GEIGY AG (CH) | 1993-11-10 | — | — | EP | disclosed |