Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 3/20 | 0.73 |
| ▸ | GAA | P10253 | 13/20 | 0.69 |
| ▸ | LMNA | P02545 | 5/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.69 |
| ▸ | MAPT | P10636 | 10/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.57 |
| ▸ | TUBB | P07437 | 3/20 | 0.57 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.57 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.57 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.57 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.57 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.57 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.57 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.57 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.57 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.57 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.57 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2919660 | 0.86 | GAA (0.66) | BRAFGAALMNAKDM4EMAPK1 | |
| SCHEMBL2923400 | 0.85 | GAA (0.83) | BRAFGAALMNAKDM4EMAPK1 | |
| SCHEMBL2913681 | 0.84 | BRAF (1.00) | BRAFGAALMNAKDM4EMAPK1 | |
| SCHEMBL2921758 | 0.84 | BRAF (0.77) | BRAFGAALMNAKDM4EMAPK1 | |
| SCHEMBL2921674 | 0.84 | BRAF (0.77) | BRAFGAALMNAKDM4EMAPK1 | |
| SCHEMBL2924128 | 0.82 | GAA (0.78) | BRAFGAALMNAKDM4EMAPK1 | |
| SCHEMBL2943722 | 0.81 | GAA (0.66) | BRAFGAALMNAKDM4EMAPK1 | |
| SCHEMBL2921992 | 0.81 | GAA (0.77) | BRAFGAALMNAKDM4EMAPK1 | |
| SCHEMBL2923964 | 0.81 | BRAF (0.69) | BRAFGAALMNAKDM4EMAPK1 | |
| SCHEMBL2948843 | 0.81 | GAA (0.78) | BRAFGAALMNAKDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1901748-B1 | ANGIOGENESIS INHIBITORS | ONCALIS AG (CH) | 2010-09-08 | — | — | EP | disclosed |
| EP-1765351-B9 | PROTEIN KINASE INHIBITORS | ONCALIS AG (CH) | 2010-03-24 | — | — | EP | disclosed |
| EP-1765351-B9 | PROTEIN KINASE INHIBITORS | ONCALIS AG (CH) | 2010-03-24 | — | — | EP | disclosed |
| EP-1765351-B1 | PROTEIN KINASE INHIBITORS | ONCALIS AG (CH) | 2009-03-04 | — | — | EP | disclosed |
| EP-1765351-B1 | PROTEIN KINASE INHIBITORS | ONCALIS AG (CH) | 2009-03-04 | — | — | EP | disclosed |
| US-20070149535-A1 | Protein kinase inhibitors | ONCALIS AG (CH) | 2007-06-28 | — | — | US | disclosed |
| US-20070149535-A1 | Protein kinase inhibitors | ONCALIS AG (CH) | 2007-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149535-A1 | Protein kinase inhibitors | FLT1, ERBB2, ERBB3 | BRAF 42/4885GAA 3677/4885LMNA 4622/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.