Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA known ✓ | P35790 | 4/20 | 0.39 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL2917182 | 1.00 | MEN1 (0.41) | MEN1KMT2AMAPTTDP1NPC1 | |
| Bromide SCHEMBL2923047 | 0.99 | MEN1 (0.40) | MEN1KMT2AMAPTTDP1NPC1 | |
| Bromide SCHEMBL2921613 | 0.99 | MEN1 (0.40) | MEN1KMT2AMAPTTDP1NPC1 | |
| Bromide SCHEMBL2921616 | 0.99 | MEN1 (0.40) | MEN1KMT2AMAPTTDP1NPC1 | |
| Bromide SCHEMBL2924313 | 0.99 | MEN1 (0.40) | MEN1KMT2AMAPTTDP1NPC1 | |
| SCHEMBL2913429 | 0.99 | MEN1 (0.42) | MEN1KMT2AMAPTTDP1NPC1 | |
| SCHEMBL2913432 | 0.99 | MEN1 (0.42) | MEN1KMT2AMAPTTDP1NPC1 | |
| Bromide SCHEMBL2921002 | 0.97 | MEN1 (0.41) | MEN1KMT2AMAPTTDP1NPC1 | |
| SCHEMBL2920381 | 0.97 | MEN1 (0.41) | MEN1KMT2AMAPTTDP1NPC1 | |
| SCHEMBL2912000 | 0.97 | MEN1 (0.41) | MEN1KMT2AMAPTTDP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1647548-B1 | Dictionic bishydrazones, dyeingcompositions containig at least one of these compounds, process of their preparation and uses thereoff | OREAL (FR) | 2010-08-25 | — | — | EP | claimed |
| US-7410506-B2 | Dicationic bis-hydrazone compound, dye composition comprising at least one such compound, implementation process therefor and uses thereof | L'OREAL S.A. (FR) | 2008-08-12 | — | — | US | claimed |
| US-20060096043-A1 | Dicationic bis-hydrazone compound, dye composition comprising at least one such compound, implementation process therefor and uses thereof | L'OREAL S.A. (FR) | 2006-05-11 | — | — | US | claimed |
| US-7410506-B2 | Dicationic bis-hydrazone compound, dye composition comprising at least one such compound, implementation process therefor and uses thereof | L'OREAL S.A. (FR) | 2008-08-12 | — | — | US | disclosed |
| US-20060096043-A1 | Dicationic bis-hydrazone compound, dye composition comprising at least one such compound, implementation process therefor and uses thereof | L'OREAL S.A. (FR) | 2006-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060096043-A1 | Dicationic bis-hydrazone compound, dye composition comprising at least one such compound, implementation process therefor and uses thereof | KRT18, DSC1, DSG1 | CHKA 1818/4885ACHE 3478/4885MEN1 1560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.