Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 9/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CCND2 | P30279 | 1/20 | 0.38 |
| ▸ | CCND3 | P30281 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.36 |
| ▸ | YES1 | P07947 | 2/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | HIPK1 | Q86Z02 | 2/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | JUN | P05412 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29173404 | 0.89 | MAPK10 (0.40) | MAPK10BRAFSYKPLK4FYN | |
| SCHEMBL24944370 | 0.83 | EML4 (0.50) | CDK4CCND3SYK | |
| SCHEMBL30205612 | 0.83 | EML4 (0.50) | CDK4CCND3SYK | |
| SCHEMBL29173405 | 0.82 | ALK (0.41) | CDK4CCND1CCND2CCND3SYK | |
| SCHEMBL29173667 | 0.77 | MAPK10 (0.41) | MAPK10CDK4CCND3SYKPLK4 | |
| SCHEMBL30206253 | 0.77 | JAK2 (0.41) | MAPK10BRAFSYKPLK4FYN | |
| SCHEMBL31577214 | 0.76 | PIK3CA (0.32) | — | |
| SCHEMBL31577217 | 0.76 | FLT3 (0.33) | SYK | |
| SCHEMBL29173344 | 0.76 | MAPK10 (0.41) | MAPK10BRAFSYKPLK4FYN | |
| SCHEMBL29173356 | 0.76 | MAPK10 (0.41) | MAPK10BRAFSYKPLK4FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |