Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30206204 | 1.00 | NPSR1 (0.47) | NPSR1ALDH1A1SMN1; SMN2KDM4ERAB9A | |
| SCHEMBL12108293 | 0.83 | NPSR1 (0.52) | NPSR1ALDH1A1SMN1; SMN2KDM4ERAB9A | |
| SCHEMBL2408051 | 0.83 | NPSR1 (0.52) | NPSR1ALDH1A1SMN1; SMN2KDM4ERAB9A | |
| SCHEMBL30205955 | 0.81 | NPSR1 (0.45) | NPSR1ALDH1A1SMN1; SMN2KDM4ERAB9A | |
| SCHEMBL29173541 | 0.81 | NPSR1 (0.45) | NPSR1ALDH1A1SMN1; SMN2KDM4ERAB9A | |
| SCHEMBL12108294 | 0.80 | NPSR1 (0.48) | NPSR1ALDH1A1SMN1; SMN2KDM4ERAB9A | |
| SCHEMBL20302593 | 0.79 | NPSR1 (0.52) | NPSR1ALDH1A1SMN1; SMN2KDM4ERAB9A | |
| SCHEMBL31214346 | 0.79 | NPSR1 (0.52) | NPSR1ALDH1A1SMN1; SMN2KDM4ERAB9A | |
| SCHEMBL29173359 | 0.79 | NPSR1 (0.44) | NPSR1ALDH1A1SMN1; SMN2KDM4ERAB9A | |
| SCHEMBL30206069 | 0.79 | NPSR1 (0.44) | NPSR1ALDH1A1SMN1; SMN2KDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |