Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20302593 | 0.92 | NPSR1 (0.52) | NPSR1SMN1; SMN2L3MBTL1RAB9ANPC1 | |
| SCHEMBL11730515 | 0.90 | NPSR1 (0.54) | NPSR1SMN1; SMN2L3MBTL1RAB9ANPC1 | |
| SCHEMBL31214346 | 0.88 | NPSR1 (0.52) | NPSR1SMN1; SMN2L3MBTL1RAB9ANPC1 | |
| SCHEMBL2408051 | 0.88 | NPSR1 (0.52) | NPSR1SMN1; SMN2L3MBTL1RAB9ANPC1 | |
| SCHEMBL30020649 | 0.86 | NPSR1 (0.54) | NPSR1SMN1; SMN2L3MBTL1RAB9ANPC1 | |
| SCHEMBL15900342 | 0.86 | NPSR1 (0.54) | NPSR1SMN1; SMN2L3MBTL1RAB9ANPC1 | |
| SCHEMBL2183292 | 0.85 | NPSR1 (0.58) | NPSR1SMN1; SMN2L3MBTL1RAB9ANPC1 | |
| SCHEMBL12108294 | 0.85 | NPSR1 (0.48) | NPSR1SMN1; SMN2L3MBTL1RAB9ANPC1 | |
| SCHEMBL31623853 | 0.83 | NPSR1 (0.47) | NPSR1SMN1; SMN2L3MBTL1RAB9ANPC1 | |
| SCHEMBL22303559 | 0.83 | NPSR1 (0.47) | NPSR1SMN1; SMN2L3MBTL1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110269741-A1 | NOVEL COMPOSITIONS AND METHODS OF USE | ARDEA BIOSCIENCES, INC. (US) | 2011-11-03 | — | — | US | disclosed |
| US-20110166123-A1 | NOVEL COMPOSITIONS AND METHODS OF USE | AARDEA BIOSCIENCES, INC. (US) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166123-A1 | NOVEL COMPOSITIONS AND METHODS OF USE | TYMP, SAMHD1, PNP | NPSR1 4732/4885SMN1; SMN2 3583/4885L3MBTL1 1224/4885 |
| US-20110269741-A1 | NOVEL COMPOSITIONS AND METHODS OF USE | TYMP, SAMHD1, PNP | NPSR1 4732/4885SMN1; SMN2 3583/4885L3MBTL1 1224/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.