Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.36 |
| ▸ | IDH1 | O75874 | 7/20 | 0.34 |
| ▸ | LCK | P06239 | 2/20 | 0.34 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | BTK | Q06187 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.32 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30206336 | 1.00 | SYK (0.36) | SYKIDH1LCKJAK3BTK | |
| SCHEMBL30206133 | 0.93 | SYK (0.33) | SYKIDH1P2RX3ALDH1A1LMNA | |
| SCHEMBL29173462 | 0.93 | SYK (0.33) | SYKIDH1P2RX3ALDH1A1LMNA | |
| SCHEMBL24944970 | 0.92 | LCK (0.40) | SYKIDH1LCKJAK3BTK | |
| SCHEMBL30206107 | 0.89 | CYP1A2 (0.35) | LCKBTKMAPTALDH1A1LMNA | |
| SCHEMBL29173378 | 0.89 | CYP1A2 (0.35) | LCKBTKMAPTALDH1A1LMNA | |
| SCHEMBL29173540 | 0.88 | SYK (0.36) | SYKLCKJAK3BTK | |
| SCHEMBL30206043 | 0.88 | SYK (0.32) | SYKLCKJAK3BTKMAPT | |
| SCHEMBL30206169 | 0.88 | SYK (0.36) | SYKLCKJAK3BTK | |
| SCHEMBL29173617 | 0.88 | SYK (0.32) | SYKLCKJAK3BTKMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |