Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.36 |
| ▸ | BTK | Q06187 | 9/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 9/20 | 0.34 |
| ▸ | ITK | Q08881 | 4/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | LYN | P07948 | 1/20 | 0.34 |
| ▸ | TEC | P42680 | 1/20 | 0.34 |
| ▸ | TXK | P42681 | 1/20 | 0.34 |
| ▸ | BMX | P51813 | 1/20 | 0.34 |
| ▸ | CD69 | Q07108 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CCND2 | P30279 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | BCR | P11274 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30206169 | 1.00 | SYK (0.36) | SYKBTKJAK3LCKEGFR | |
| SCHEMBL29173617 | 0.93 | SYK (0.32) | SYKBTKJAK3LCKEGFR | |
| SCHEMBL30206043 | 0.93 | SYK (0.32) | SYKBTKJAK3LCKEGFR | |
| SCHEMBL24944978 | 0.93 | BTK (0.41) | SYKBTKJAK3LCKEGFR | |
| SCHEMBL29173670 | 0.91 | BTK (0.37) | SYKBTKJAK3LCKEGFR | |
| SCHEMBL30206119 | 0.91 | BTK (0.37) | SYKBTKJAK3LCKEGFR | |
| SCHEMBL29173448 | 0.88 | SYK (0.36) | SYKBTKJAK3LCK | |
| SCHEMBL30206336 | 0.88 | SYK (0.36) | SYKBTKJAK3LCK | |
| SCHEMBL29173653 | 0.88 | BTK (0.37) | BTK | |
| SCHEMBL29173378 | 0.87 | CYP1A2 (0.35) | BTKLCKITKCDK4CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |