Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30205968 | 1.00 | HPGD (0.32) | HPGDMAPK1TYK2YTHDC1 | |
| SCHEMBL29173658 | 0.91 | BUB1 (0.34) | — | |
| SCHEMBL29173644 | 0.90 | — | — | |
| SCHEMBL30206269 | 0.90 | — | — | |
| SCHEMBL24944982 | 0.90 | TYK2 (0.37) | TYK2 | |
| SCHEMBL30205499 | 0.90 | TYK2 (0.37) | TYK2 | |
| SCHEMBL29173378 | 0.88 | CYP1A2 (0.35) | YTHDC1 | |
| SCHEMBL30206107 | 0.88 | CYP1A2 (0.35) | YTHDC1 | |
| SCHEMBL31195396 | 0.87 | SYK (0.31) | — | |
| SCHEMBL29173666 | 0.87 | HPGD (0.32) | HPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |