Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 2/20 | 0.32 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30205499 | 1.00 | TYK2 (0.37) | TYK2EML4ALKSYKPFKFB3 | |
| SCHEMBL24944179 | 0.92 | LRRK2 (0.33) | TYK2EML4ALKSYKLRRK2 | |
| SCHEMBL30205755 | 0.92 | LRRK2 (0.33) | TYK2EML4ALKSYKLRRK2 | |
| SCHEMBL30206301 | 0.92 | TYK2 (0.31) | TYK2 | |
| SCHEMBL24944480 | 0.92 | TYK2 (0.31) | TYK2 | |
| SCHEMBL24944974 | 0.91 | ALK (0.34) | TYK2EML4ALKSYKPFKFB3 | |
| SCHEMBL29173474 | 0.90 | HPGD (0.32) | TYK2 | |
| SCHEMBL30205968 | 0.90 | HPGD (0.32) | TYK2 | |
| SCHEMBL24944445 | 0.89 | SYK (0.31) | EML4ALKSYK | |
| SCHEMBL30205684 | 0.89 | SYK (0.31) | EML4ALKSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | claimed |
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |