Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 4/20 | 0.40 |
| ▸ | CDK4 | P11802 | 3/20 | 0.40 |
| ▸ | CDK1 | P06493 | 2/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.40 |
| ▸ | CCND1 | P24385 | 2/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.39 |
| ▸ | EML4 | Q9HC35 | 3/20 | 0.38 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.37 |
| ▸ | SYK | P43405 | 4/20 | 0.37 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.36 |
| ▸ | YES1 | P07947 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30206250 | 1.00 | CDK2 (0.40) | CDK2CDK4CDK1CCNB1CCND1 | |
| SCHEMBL29173457 | 0.95 | CDK2 (0.39) | CDK2CDK4CDK1CCNB1CCND1 | |
| SCHEMBL30206144 | 0.95 | CDK2 (0.39) | CDK2CDK4CDK1CCNB1CCND1 | |
| SCHEMBL30205510 | 0.92 | EML4 (0.47) | CDK2CDK4ALKLCKJAK3 | |
| SCHEMBL24944955 | 0.92 | EML4 (0.47) | CDK2CDK4ALKLCKJAK3 | |
| SCHEMBL30205974 | 0.90 | CDK1 (0.39) | CDK2CDK4CDK1CCNB1CCND1 | |
| SCHEMBL29173625 | 0.90 | CDK1 (0.39) | CDK2CDK4CDK1CCNB1CCND1 | |
| SCHEMBL30206147 | 0.90 | PKMYT1 (0.41) | CDK2CDK4ALKJAK3INSR | |
| SCHEMBL30206202 | 0.89 | PKMYT1 (0.40) | CDK2CDK4CDK1CCNB1CCND1 | |
| SCHEMBL29173512 | 0.89 | PKMYT1 (0.40) | CDK2CDK4CDK1CCNB1CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |