Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 2/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND3 | P30281 | 1/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | STAT6 | P42226 | 2/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30205764 | 0.93 | EML4 (0.45) | JAK3CCNA2CDK2AURKACDK4 | |
| SCHEMBL24944959 | 0.93 | EML4 (0.45) | JAK3CCNA2CDK2AURKACDK4 | |
| SCHEMBL30206147 | 0.92 | PKMYT1 (0.41) | PIM1JAK2JAK3PKMYT1CCNA2 | |
| SCHEMBL29173586 | 0.91 | PIM1 (0.41) | PIM1JAK2JAK3CCNA2CDK2 | |
| SCHEMBL29173582 | 0.91 | PIM1 (0.41) | PIM1JAK2JAK3PKMYT1CCNA2 | |
| SCHEMBL29173706 | 0.89 | JAK2 (0.43) | PIM1JAK2JAK3DGAT1CCNA2 | |
| SCHEMBL30206091 | 0.89 | JAK2 (0.43) | PIM1JAK2JAK3DGAT1CCNA2 | |
| SCHEMBL30205765 | 0.84 | EML4 (0.45) | JAK3CCNA2CDK2AURKACDK4 | |
| SCHEMBL24944729 | 0.84 | EML4 (0.45) | JAK3CCNA2CDK2AURKACDK4 | |
| SCHEMBL24943791 | 0.84 | EML4 (0.48) | JAK3CCNA2CDK2AURKACDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |