Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 8/20 | 0.37 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.33 |
| ▸ | BRAF | P15056 | 4/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30206248 | 1.00 | LRRK2 (0.37) | LRRK2ZAP70EGFRIRAK4BRAF | |
| SCHEMBL24943794 | 0.92 | RET (0.38) | LRRK2IRAK4MAPK9MAPK10 | |
| SCHEMBL30205976 | 0.89 | LRRK2 (0.35) | LRRK2ZAP70EGFR | |
| SCHEMBL29173615 | 0.89 | LRRK2 (0.35) | LRRK2ZAP70EGFR | |
| SCHEMBL29173329 | 0.89 | SYK (0.41) | EGFRIRAK4MAPK9MAPK10 | |
| SCHEMBL29173428 | 0.89 | LRRK2 (0.36) | LRRK2ZAP70EGFRIRAK4MAPK9 | |
| SCHEMBL30206019 | 0.89 | SYK (0.41) | EGFRIRAK4MAPK9MAPK10 | |
| SCHEMBL30206349 | 0.89 | LRRK2 (0.36) | LRRK2ZAP70EGFRIRAK4MAPK9 | |
| SCHEMBL29173445 | 0.88 | ZAP70 (0.43) | LRRK2ZAP70EGFRIRAK4MAPK9 | |
| SCHEMBL29173545 | 0.87 | ZAP70 (0.36) | LRRK2ZAP70EGFRIRAK4MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |