Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 17/20 | 0.36 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.33 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | PLK4 | O00444 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | PAK4 | O96013 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30206349 | 1.00 | LRRK2 (0.36) | LRRK2ZAP70TTKJAK2MKNK2 | |
| SCHEMBL29173615 | 0.94 | LRRK2 (0.35) | LRRK2ZAP70TTKJAK2MKNK2 | |
| SCHEMBL30205976 | 0.94 | LRRK2 (0.35) | LRRK2ZAP70TTKJAK2MKNK2 | |
| SCHEMBL30206108 | 0.94 | ZAP70 (0.36) | LRRK2ZAP70TTKJAK2MKNK2 | |
| SCHEMBL29173545 | 0.94 | ZAP70 (0.36) | LRRK2ZAP70TTKJAK2MKNK2 | |
| SCHEMBL24944442 | 0.92 | RET (0.37) | LRRK2ZAP70PLK4AURKAEGFR | |
| SCHEMBL29173445 | 0.89 | ZAP70 (0.43) | LRRK2ZAP70JAK2MKNK2PTK2 | |
| SCHEMBL30206248 | 0.89 | LRRK2 (0.37) | LRRK2ZAP70EGFRMAPK9MAPK10 | |
| SCHEMBL29173569 | 0.89 | LRRK2 (0.37) | LRRK2ZAP70EGFRMAPK9MAPK10 | |
| SCHEMBL29173530 | 0.88 | LRRK2 (0.37) | LRRK2ZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |