Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 3/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | PKMYT1 | Q99640 | 5/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 2/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30206183 | 1.00 | PTK2 (0.41) | PTK2EGFRPKMYT1FGFR1SRC | |
| SCHEMBL30206027 | 0.93 | BTK (0.40) | PTK2PKMYT1BTKMAPTMAPK1 | |
| SCHEMBL29173536 | 0.93 | BTK (0.40) | PTK2PKMYT1BTKMAPTMAPK1 | |
| SCHEMBL30206034 | 0.93 | PKMYT1 (0.40) | PTK2EGFRPKMYT1BTKMAPT | |
| SCHEMBL29173612 | 0.93 | PKMYT1 (0.40) | PTK2EGFRPKMYT1BTKMAPT | |
| SCHEMBL30206236 | 0.92 | PKMYT1 (0.40) | PTK2EGFRPKMYT1BTKMAPT | |
| SCHEMBL29173689 | 0.92 | PKMYT1 (0.40) | PKMYT1BTKALKMAPTMAPK1 | |
| SCHEMBL30206259 | 0.92 | PKMYT1 (0.40) | PKMYT1BTKALKMAPTMAPK1 | |
| SCHEMBL29173355 | 0.92 | PKMYT1 (0.40) | PTK2EGFRPKMYT1BTKMAPT | |
| SCHEMBL24944946 | 0.91 | EML4 (0.46) | PTK2PKMYT1FGFR1SRCALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |