Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EML4 | Q9HC35 | 6/20 | 0.56 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.56 |
| ▸ | RET | P07949 | 5/20 | 0.51 |
| ▸ | ROS1 | P08922 | 5/20 | 0.51 |
| ▸ | FLT3 | P36888 | 5/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | CDK4 | P11802 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | CCND3 | P30281 | 1/20 | 0.48 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 4/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | STAT6 | P42226 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30206344 | 1.00 | EML4 (0.56) | EML4ALKRETROS1FLT3 | |
| SCHEMBL30206048 | 0.88 | MAPT (0.49) | EML4ALKTP53MAPK1MAPT | |
| SCHEMBL29173619 | 0.88 | MAPT (0.49) | EML4ALKTP53MAPK1MAPT | |
| SCHEMBL31195393 | 0.81 | EML4 (0.51) | EML4ALKRETROS1FLT3 | |
| SCHEMBL30205943 | 0.81 | SYK (0.53) | EML4ALKAURKACDK4CCNA2 | |
| SCHEMBL29173352 | 0.81 | SYK (0.53) | EML4ALKAURKACDK4CCNA2 | |
| SCHEMBL13405489 | 0.81 | PIM1 (0.64) | EML4ALKRETROS1FLT3 | |
| SCHEMBL30206068 | 0.79 | EML4 (0.58) | EML4ALKRETROS1FLT3 | |
| SCHEMBL29173494 | 0.79 | EML4 (0.58) | EML4ALKRETROS1FLT3 | |
| SCHEMBL10126777 | 0.78 | EML4 (0.67) | EML4ALKRETROS1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |