Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 5/20 | 0.73 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2120180 | 0.86 | ERN1 (1.00) | ERN1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL29371317 | 0.86 | ERN1 (1.00) | ERN1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| Alcohol SCHEMBL28685702 | 0.81 | ERN1 (0.81) | ERN1MAPTMEN1KMT2AHSP90AA1 | |
| SCHEMBL29285286 | 0.81 | ERN1 (0.69) | ERN1MAPTMEN1KMT2AHSP90AA1 | |
| SCHEMBL27923095 | 0.80 | ERN1 (0.73) | ERN1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| 5-Bromosalicylaldehyde SCHEMBL29175395 | 0.77 | ERN1 (0.73) | ERN1MAPTMEN1KMT2APTGDR2 | |
| SCHEMBL29285288 | 0.77 | ERN1 (0.73) | ERN1MAPTMEN1KMT2AHSP90AA1 | |
| SCHEMBL28007480 | 0.76 | ERN1 (0.67) | ERN1MAPTMEN1KMT2AHSP90AA1 | |
| SCHEMBL544809 | 0.75 | ERN1 (0.78) | ERN1TDP1CYP3A4TSHRPTGDR2 | |
| SCHEMBL4998278 | 0.75 | ERN1 (0.55) | ERN1MEN1KMT2APTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117586433-A | N, N, N-trimethyl chitosan quaternary ammonium salt containing glycine Schiff base and preparation and application thereof | 中国科学院烟台海岸带研究所 | 2024-02-23 | — | — | CN | disclosed |