Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 10/20 | 0.73 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27925777 | 0.86 | ERN1 (1.00) | ERN1POLBCA2CA1CDK1 | |
| SCHEMBL247839 | 0.86 | ERN1 (1.00) | ERN1POLBCA2CA1CDK1 | |
| SCHEMBL29694515 | 0.86 | ERN1 (1.00) | ERN1POLBCA2CA1CDK1 | |
| SCHEMBL11407251 | 0.84 | ERN1 (0.96) | ERN1POLBCA2CA1CDK1 | |
| SCHEMBL11530954 | 0.84 | ERN1 (0.96) | ERN1POLBCDK1TDP1ALDH1A1 | |
| Glycine SCHEMBL28062857 | 0.83 | ERN1 (0.47) | ERN1POLBCDK1TDP1ALDH1A1 | |
| Alcohol SCHEMBL28460788 | 0.81 | ERN1 (0.81) | ERN1POLBCDK1TDP1ALDH1A1 | |
| SCHEMBL10428091 | 0.81 | ERN1 (0.69) | ERN1CA2CA1CDK1TDP1 | |
| Alanine SCHEMBL28107968 | 0.81 | ERN1 (0.69) | ERN1CA2CA1TDP1CA12 | |
| 5-Bromosalicylaldehyde SCHEMBL29175395 | 0.80 | ERN1 (0.73) | ERN1POLBCDK1GAACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117586433-A | N, N, N-trimethyl chitosan quaternary ammonium salt containing glycine Schiff base and preparation and application thereof | 中国科学院烟台海岸带研究所 | 2024-02-23 | — | — | CN | disclosed |