Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 8/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 2/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL36835 | 0.84 | ERN1 (0.61) | ERN1CDK1EGFRALDH1A1MAPT | |
| Glycine SCHEMBL29175397 | 0.83 | ERN1 (0.73) | ERN1CDK1ALDH1A1POLBGAA | |
| 5-Bromosalicylaldehyde SCHEMBL29175395 | 0.83 | ERN1 (0.73) | ERN1CDK1MAPTKDM4EPOLB | |
| Formamide SCHEMBL28912568 | 0.83 | ERN1 (0.55) | ERN1CDK1EGFRALDH1A1MAPT | |
| Hydroquinone SCHEMBL11562733 | 0.82 | ERN1 (0.59) | ERN1CDK1EGFRALDH1A1MAPT | |
| SCHEMBL4456289 | 0.82 | ERN1 (0.59) | ERN1CDK1EGFRALDH1A1MAPT | |
| Formaldehyde SCHEMBL28912569 | 0.79 | ERN1 (0.55) | ERN1CDK1EGFRALDH1A1MAPT | |
| Salicyladehyde SCHEMBL15016 | 0.78 | TRIM24 (0.69) | ERN1MAPTKDM4ETDP1 | |
| Sulfurous Acid SCHEMBL11594092 | 0.77 | ERN1 (0.53) | ERN1CDK1EGFRALDH1A1MAPT | |
| Glycine SCHEMBL28865263 | 0.77 | ERN1 (0.74) | ERN1ALDH1A1MAPTKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104130236-B | Catalyzed conversion CO under normal pressure 2the method of synthesizing annular carbonate | BEIJING INSTITUTE OF TECHNOLOGY (CN) | 2016-04-27 | — | — | CN | disclosed |