Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.81 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | HTR1A | P08908 | 1/20 | 0.62 |
| ▸ | HTR1D | P28221 | 1/20 | 0.62 |
| ▸ | HTR1B | P28222 | 1/20 | 0.62 |
| ▸ | HTR2C | P28335 | 1/20 | 0.62 |
| ▸ | HTR6 | P50406 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | RBP4 | P02753 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3716149 | 0.86 | POLB (0.75) | POLBPANK3KMT2AMEN1HTR1A | |
| SCHEMBL26758583 | 0.85 | POLB (0.65) | POLBPANK3KMT2AMAPTALDH1A1 | |
| SCHEMBL26758522 | 0.82 | PANK3 (0.64) | POLBPANK3KMT2AHTR1AHTR1D | |
| SCHEMBL27652942 | 0.81 | NPC1 (0.83) | POLBKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL12994627 | 0.81 | CA12 (0.76) | POLBKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL26758591 | 0.79 | MAPT (0.84) | POLBPANK3MAPTALDH1A1KDM4E | |
| SCHEMBL26758590 | 0.78 | CA12 (0.78) | POLBPANK3KMT2AMAPTALDH1A1 | |
| SCHEMBL12529017 | 0.78 | POLB (0.62) | POLBPANK3KMT2AMEN1HTR1A | |
| SCHEMBL4386926 | 0.78 | POLB (0.59) | POLBPANK3KMT2AMEN1HTR1A | |
| SCHEMBL16299030 | 0.77 | KDM4E (0.69) | POLBKMT2AMEN1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117736163-A | Phenylpiperazine derivative or pharmaceutical salt thereof, preparation method and application thereof in preparation of pain treatment drugs | 郑州大学第一附属医院 | 2024-03-22 | — | — | CN | claimed |
| CN-117736163-A | Phenylpiperazine derivative or pharmaceutical salt thereof, preparation method and application thereof in preparation of pain treatment drugs | 郑州大学第一附属医院 | 2024-03-22 | — | — | CN | disclosed |