Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.75 |
| ▸ | HTR1A | P08908 | 1/20 | 0.59 |
| ▸ | HTR1D | P28221 | 1/20 | 0.59 |
| ▸ | HTR1B | P28222 | 1/20 | 0.59 |
| ▸ | HTR2C | P28335 | 1/20 | 0.59 |
| ▸ | HTR6 | P50406 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.57 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | RBP4 | P02753 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3710143 | 0.86 | SMN1; SMN2 (0.65) | POLBHTR1AHTR1DHTR1BHTR2C | |
| SCHEMBL29178288 | 0.86 | POLB (0.81) | POLBHTR1AHTR1DHTR1BHTR2C | |
| SCHEMBL3716167 | 0.86 | TRPV1 (0.75) | KMT2AMEN1TRPV1RBP4 | |
| SCHEMBL3713332 | 0.85 | MEN1 (0.59) | POLBHTR1AHTR1DHTR1BHTR2C | |
| SCHEMBL3705471 | 0.82 | TRPV1 (0.62) | TRPV1 | |
| SCHEMBL3781732 | 0.82 | CA12 (0.71) | POLBKMT2AMEN1TRPV1MAPT | |
| SCHEMBL3714314 | 0.81 | TRPV1 (0.60) | POLBHTR1AHTR1DHTR1BHTR2C | |
| SCHEMBL3709637 | 0.78 | KDM4E (0.78) | POLBKMT2AMEN1L3MBTL1PANK3 | |
| SCHEMBL3712388 | 0.78 | PDGFRB (0.62) | KMT2AMEN1TRPV1MAPTKDM4E | |
| SCHEMBL3709422 | 0.77 | LMNA (0.53) | POLBPANK3TRPV1MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010092342-A1 | ORGANOSILICON COMPOUNDS AND THEIR USE AS THE MODULATORS OF THE TRPV1 RECEPTOR | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-19 | — | — | WO | disclosed |