Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3
The experimentally established mechanism targets of L-Norepinephrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 4/20 | 0.92 |
| ▸ | ADRB1 known ✓ | P08588 | 3/20 | 0.92 |
| ▸ | ADRA2A known ✓ | P08913 | 3/20 | 0.92 |
| ▸ | ADRA2B known ✓ | P18089 | 3/20 | 0.92 |
| ▸ | ADRA2C known ✓ | P18825 | 3/20 | 0.92 |
| ▸ | ADRA1D known ✓ | P25100 | 3/20 | 0.92 |
| ▸ | ADRB3 known ✓ | P13945 | 2/20 | 0.92 |
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 0.92 |
| ▸ | ADRA1B known ✓ | P35368 | 2/20 | 0.92 |
| ▸ | BLM | P54132 | 6/20 | 0.92 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.92 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.92 |
| ▸ | MAPT | P10636 | 5/20 | 0.92 |
| ▸ | RECQL | P46063 | 4/20 | 0.92 |
| ▸ | APEX1 | P27695 | 4/20 | 0.92 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.92 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.92 |
| ▸ | MEN1 | O00255 | 3/20 | 0.92 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.92 |
| ▸ | HPGD | P15428 | 2/20 | 0.92 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| L-Norepinephrine SCHEMBL317206 | 0.98 | BLM (0.96) | BLMTDP1KDM4EMAPTRECQL | |
| Norepinephrine SCHEMBL2249 | 0.98 | BLM (0.96) | BLMTDP1KDM4EMAPTRECQL | |
| L-Norepinephrine SCHEMBL31281490 | 0.98 | BLM (0.96) | BLMTDP1KDM4EMAPTRECQL | |
| Norepinephrine SCHEMBL31352030 | 0.98 | BLM (0.96) | BLMTDP1KDM4EMAPTRECQL | |
| Norepinephrine SCHEMBL2609 | 0.96 | TDP1 (1.00) | BLMTDP1KDM4EMAPTRECQL | |
| L-Norepinephrine SCHEMBL29460319 | 0.96 | TDP1 (1.00) | BLMTDP1KDM4EMAPTRECQL | |
| Norepinephrine SCHEMBL2429869 | 0.96 | TDP1 (1.00) | BLMTDP1KDM4EMAPTRECQL | |
| L-Norepinephrine SCHEMBL3489077 | 0.96 | TDP1 (1.00) | BLMTDP1KDM4EMAPTRECQL | |
| L-Norepinephrine SCHEMBL29371849 | 0.96 | TDP1 (1.00) | BLMTDP1KDM4EMAPTRECQL | |
| Norepinephrine SCHEMBL29399946 | 0.96 | TDP1 (1.00) | BLMTDP1KDM4EMAPTRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113748101-B | Process for the preparation of enantiomerically pure norepinephrine | 爱德蒙制药责任有限公司 | 2024-04-02 | — | — | CN | disclosed |