Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 13/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 11/20 | 0.52 |
| ▸ | CDK2 | P24941 | 11/20 | 0.52 |
| ▸ | CCNA1 | P78396 | 11/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15026293 | 0.82 | CHEK1 (0.64) | CHEK1CCNA2CDK2CCNA1MEN1 | |
| SCHEMBL2704383 | 0.81 | MTOR (0.38) | CHEK1CCNA2CDK2CCNA1MEN1 | |
| SCHEMBL21483 | 0.80 | CHEK1 (0.56) | CHEK1CCNA2CDK2CCNA1MEN1 | |
| SCHEMBL17850056 | 0.80 | CHEK1 (0.56) | CHEK1CCNA2CDK2CCNA1MEN1 | |
| SCHEMBL15007512 | 0.80 | CHEK1 (0.56) | CHEK1CCNA2CDK2CCNA1MEN1 | |
| SCHEMBL20332 | 0.80 | CHEK1 (0.52) | CHEK1CCNA2CDK2CCNA1MEN1 | |
| SCHEMBL12460566 | 0.79 | CHEK1 (0.57) | CHEK1CCNA2CDK2CCNA1MEN1 | |
| SCHEMBL14246610 | 0.79 | CHEK1 (0.57) | CHEK1CCNA2CDK2CCNA1MEN1 | |
| SCHEMBL14245841 | 0.79 | CHEK1 (0.57) | CHEK1CCNA2CDK2CCNA1MEN1 | |
| SCHEMBL15007509 | 0.79 | CHEK1 (0.55) | CHEK1CCNA2CDK2CCNA1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2608668-A1 | FUSED TRICYCLIC INHIBITORS OF MAMMALIAN TARGET OF RAPAMYCIN | Merck Sharp & Dohme Corp. (US) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012027234-A1 | FUSED TRICYCLIC INHIBITORS OF MAMMALIAN TARGET OF RAPAMYCIN | SCHERING CORPORATION (US) | 2012-03-01 | — | — | WO | disclosed |