Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.40 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.39 |
| ▸ | TEK | Q02763 | 2/20 | 0.39 |
| ▸ | TGM2 | P21980 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP4 | P49662 | 1/20 | 0.36 |
| ▸ | CASP5 | P51878 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29185654 | 0.84 | KDM4E (0.42) | KDM4EALDH1A1KMT2AHDAC1HDAC7 | |
| SCHEMBL2900590 | 0.83 | KDM4E (0.35) | KDM4EALDH1A1KMT2AKLKB1 | |
| SCHEMBL29185672 | 0.83 | KDM4E (0.41) | KDM4EALDH1A1KMT2AHDAC1HDAC7 | |
| SCHEMBL2161366 | 0.77 | KLKB1 (0.40) | KDM4EALDH1A1KMT2AKLKB1 | |
| SCHEMBL2187316 | 0.76 | — | — | |
| SCHEMBL30122138 | 0.74 | KLKB1 (0.43) | KDM4EALDH1A1KMT2AKLKB1 | |
| SCHEMBL24628398 | 0.73 | KMT2A (0.59) | KDM4EALDH1A1KMT2AHDAC1EPHB4 | |
| SCHEMBL18577743 | 0.73 | HDAC1 (0.58) | KDM4EALDH1A1HDAC1HDAC7EPHB4 | |
| SCHEMBL17066899 | 0.73 | NPC1 (0.44) | KDM4EALDH1A1KMT2A | |
| SCHEMBL2186778 | 0.73 | KDM4E (0.30) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4346805-A1 | PYRIMIDINE AND PYRIDINE AMINE COMPOUNDS AND USAGE THEREOF IN DISEASE TREATMENT | Epigen Biosciences, Inc. (US) | 2024-04-10 | — | — | EP | disclosed |
| CN-117500496-A | Pyrimidine and pyridinamine compounds and their use in the treatment of diseases | 艾匹根生物技术有限公司 | 2024-02-02 | — | — | CN | disclosed |
| WO-2022256075-A1 | PYRIMIDINE AND PYRIDINE AMINE COMPOUNDS AND USAGE THEREOF IN DISEASE TREATMENT | EPIGEN BIOSCIENCES, INC. (US) | 2022-12-08 | — | — | WO | disclosed |