SCHEMBL29187243

SCHEMBL29187243

FC(F)C(F)(Oc1nc2ccccc2nc1C#Cc1ccccc1)C(F)(F)F

nearest known ligand 0.35

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 1/20 0.35
GRM5 P41594 4/20 0.33
APP P05067 1/20 0.32
KCNH2 Q12809 1/20 0.32
EGFR P00533 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12669915 0.77 ADORA2A (0.41) ADORA2AGRM5APPKCNH2EGFR
SCHEMBL30829266 0.77 ADORA2A (0.38) ADORA2AGRM5APPKCNH2EGFR
SCHEMBL29187253 0.76 CYP1A2 (0.34)
SCHEMBL29187260 0.75 TDP1 (0.42)
SCHEMBL15958624 0.72 GRM5 (0.48) ADORA2AGRM5APPKCNH2EGFR
SCHEMBL13595046 0.69 KDM4E (0.45) ADORA2AEGFR
SCHEMBL12669918 0.67 CYP1A2 (0.44) ADORA2AGRM5APPKCNH2
SCHEMBL12669917 0.66 GRM5 (0.46) GRM5KCNH2
SCHEMBL29187245 0.64 CFB (0.32)
SCHEMBL6934550 0.64 MAPT (0.52) ADORA2AGRM5APPKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117702139-A Method for synthesizing electrocatalytic fluoroalkoxy aryl ether compound 西华师范大学 2024-03-15 CN disclosed