Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.59 |
| ▸ | RAB9A | P51151 | 8/20 | 0.59 |
| ▸ | NPC1 | O15118 | 6/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | GLA | P06280 | 1/20 | 0.59 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.59 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.59 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.59 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.59 |
| ▸ | CBFB | Q13951 | 1/20 | 0.59 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | ELANE | P08246 | 1/20 | 0.48 |
| ▸ | LDHA | P00338 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13177201 | 0.87 | KDM4E (0.58) | KDM4ERAB9ANPC1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL2921145 | 0.85 | KDM4E (0.56) | KDM4ERAB9ANPC1MEN1KMT2A | |
| SCHEMBL2927953 | 0.84 | KDM4E (0.55) | KDM4ERAB9ANPC1MEN1KMT2A | |
| SCHEMBL2921048 | 0.81 | KDM4E (0.51) | KDM4ERAB9ANPC1MEN1KMT2A | |
| SCHEMBL2926846 | 0.80 | MCHR1 (0.65) | KDM4ERAB9ANPC1MEN1KMT2A | |
| SCHEMBL2175124 | 0.80 | NPC1 (0.67) | KDM4ERAB9ANPC1MEN1KMT2A | |
| SCHEMBL17432454 | 0.80 | KDM4E (0.65) | KDM4ERAB9ANPC1MEN1KMT2A | |
| SCHEMBL2922304 | 0.79 | MCHR1 (0.64) | KDM4ERAB9ANPC1MEN1KMT2A | |
| SCHEMBL13594195 | 0.78 | KDM4E (0.63) | KDM4ERAB9ANPC1MEN1KMT2A | |
| SCHEMBL2923647 | 0.78 | KDM4E (0.52) | KDM4ERAB9ANPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1285651-B1 | MELANIN CONCENTRATING HORMONE ANTAGONISTS | TAKEDA PHARMACEUTICAL (JP) | 2010-09-01 | — | — | EP | disclosed |
| EP-1285651-B1 | MELANIN CONCENTRATING HORMONE ANTAGONISTS | TAKEDA PHARMACEUTICAL (JP) | 2010-09-01 | — | — | EP | disclosed |
| US-6930185-B2 | Melanin-concentrating hormone antagonist | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2005-08-16 | — | — | US | disclosed |
| US-20040077628-A1 | Melanin-concentrating hormone antagonist | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-04-22 | — | — | US | disclosed |
| EP-1285651-A1 | MELANIN CONCENTRATING HORMONE ANTAGONISTS | Takeda Chemical Industries, Ltd. (JP) | 2003-02-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040077628-A1 | Melanin-concentrating hormone antagonist | MCHR1, MC1R, MCHR2 | KDM4E 2403/4885RAB9A 1132/4885NPC1 1013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.