Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.45 |
| ▸ | PDE4A | P27815 | 4/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.44 |
| ▸ | TOP2A | P11388 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PYGL | P06737 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PDE1A | P54750 | 1/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29189691 | 0.88 | PDE4B (0.44) | PDE5AKDM4EALDH1A1PDE4DPDE4A | |
| SCHEMBL23958622 | 0.83 | PDE5A (0.43) | PDE5AKDM4EALDH1A1PDE4DPDE4A | |
| SCHEMBL30117191 | 0.82 | NOTUM (0.54) | PDE5AKDM4EALDH1A1PDE4DPDE4A | |
| SCHEMBL23704079 | 0.82 | NOTUM (0.54) | PDE5AKDM4EALDH1A1PDE4DPDE4A | |
| SCHEMBL24751982 | 0.82 | EPHX2 (0.44) | PDE5AKDM4EALDH1A1PDE4DPDE4A | |
| SCHEMBL30138077 | 0.82 | EPHX2 (0.44) | PDE5AKDM4EALDH1A1PDE4DPDE4A | |
| SCHEMBL18031253 | 0.82 | MAPT (0.53) | PDE5APDE4DPDE4APDE4BPDE4C | |
| SCHEMBL16544967 | 0.80 | MAPT (0.62) | PDE5APDE4DPDE4APDE4BPDE4C | |
| SCHEMBL18031244 | 0.80 | CA12 (0.57) | PDE5AKDM4EALDH1A1PDE4DPDE4A | |
| SCHEMBL29208134 | 0.79 | ALDH1A1 (0.42) | PDE5AKDM4EALDH1A1PDE4DPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117881681-A | Substituted pyrrolo [2,3-d ] pyrimidines, their preparation and their therapeutic use | 赛诺菲 | 2024-04-12 | — | — | CN | disclosed |