SCHEMBL29189888

SCHEMBL29189888

CC1CCCN(Cc2cc(C(F)(F)F)c3oc(-c4cccc(-c5ccccc5-c5nncn5C)c4)nc3c2)C1

nearest known ligand 0.44

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ CBLB Q13191 10/20 0.44
▸ S1PR1 P21453 6/20 0.40
▸ S1PR3 Q99500 5/20 0.40
▸ CNR2 P34972 2/20 0.37
▸ PDCD1 Q15116 2/20 0.36
▸ CD274 Q9NZQ7 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30153015 1.00 CBLB (0.44) CBLBS1PR1S1PR3CNR2PDCD1
SCHEMBL30152952 1.00 CBLB (0.44) CBLBS1PR1S1PR3CNR2PDCD1
SCHEMBL24818788 1.00 CBLB (0.44) CBLBS1PR1S1PR3CNR2PDCD1
SCHEMBL24819900 1.00 CBLB (0.44) CBLBS1PR1S1PR3CNR2PDCD1
SCHEMBL24818829 0.93 CBLB (0.42) CBLBS1PR1S1PR3CNR2
SCHEMBL29189890 0.91 CBLB (0.44) CBLBS1PR1S1PR3CNR2PDCD1
SCHEMBL24819909 0.91 CBLB (0.42) CBLBS1PR1S1PR3CNR2PDCD1
SCHEMBL29190031 0.91 CBLB (0.42) CBLBS1PR1S1PR3CNR2PDCD1
SCHEMBL30153161 0.91 CBLB (0.42) CBLBS1PR1S1PR3CNR2PDCD1
SCHEMBL24820254 0.90 CBLB (0.41) CBLBS1PR1S1PR3CNR2PDCD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117858865-A CBL-B modulators and uses thereof 林伯士克莱奥公司 2024-04-09 — — CN disclosed
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