SCHEMBL29190091

SCHEMBL29190091

CC1CCCN(Cc2cc(C(F)(F)F)c3[nH]c(-c4cc(-c5ccc(F)cc5-c5nncn5C)cc(C5CC5)n4)nc3c2)C1

nearest known ligand 0.38

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ CBLB Q13191 12/20 0.38
▸ CNR2 P34972 1/20 0.34
▸ PDE2A O00408 3/20 0.31
▸ MAP3K5 Q99683 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30152734 1.00 CBLB (0.38) CBLBCNR2PDE2AMAP3K5
SCHEMBL24820601 1.00 CBLB (0.38) CBLBCNR2PDE2AMAP3K5
SCHEMBL30152576 0.90 CBLB (0.42) CBLBCNR2PDE2A
SCHEMBL24818660 0.90 CBLB (0.42) CBLBCNR2PDE2A
SCHEMBL24818903 0.88 CBLB (0.39) CBLB
SCHEMBL30152932 0.88 CBLB (0.39) CBLB
SCHEMBL24820706 0.86 CBLB (0.39) CBLB
SCHEMBL30152762 0.86 CBLB (0.39) CBLB
SCHEMBL24818957 0.86 CBLB (0.38) CBLBPDE2AMAP3K5
SCHEMBL30152918 0.86 CBLB (0.38) CBLBPDE2AMAP3K5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117858865-A CBL-B modulators and uses thereof 林伯士克莱奥公司 2024-04-09 — — CN disclosed
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