Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 1/20 | 0.76 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.76 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.76 |
| ▸ | RAB9A | P51151 | 9/20 | 0.73 |
| ▸ | NPC1 | O15118 | 8/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.71 |
| ▸ | MAPT | P10636 | 2/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
| ▸ | GAA | P10253 | 1/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.71 |
| ▸ | GFER | P55789 | 1/20 | 0.71 |
| ▸ | ESRRG | P62508 | 3/20 | 0.68 |
| ▸ | MLYCD | O95822 | 2/20 | 0.68 |
| ▸ | ESRRB | O95718 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.66 |
| ▸ | SYK | P43405 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5594655 | 0.93 | RAB9A (0.71) | HDAC2HDAC8HDAC6RAB9ANPC1 | |
| SCHEMBL31420450 | 0.91 | NPC1 (0.84) | HDAC2HDAC8HDAC6RAB9ANPC1 | |
| SCHEMBL14302481 | 0.91 | MEN1 (0.69) | HDAC2HDAC8HDAC6RAB9ANPC1 | |
| SCHEMBL751214 | 0.89 | HDAC2 (0.80) | HDAC2HDAC8HDAC6RAB9ANPC1 | |
| SCHEMBL11711200 | 0.89 | RAB9A (0.66) | HDAC2HDAC8HDAC6RAB9ANPC1 | |
| SCHEMBL14302482 | 0.88 | RAB9A (0.65) | HDAC2HDAC8HDAC6RAB9ANPC1 | |
| SCHEMBL7282271 | 0.88 | HDAC2 (0.78) | HDAC2HDAC8HDAC6RAB9ANPC1 | |
| SCHEMBL6841899 | 0.88 | HDAC2 (0.78) | HDAC2HDAC8HDAC6RAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL28193721 | 0.87 | HDAC2 (0.77) | HDAC2HDAC8HDAC6RAB9ANPC1 | |
| SCHEMBL26844450 | 0.87 | HDAC2 (0.58) | HDAC2HDAC8HDAC6RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113950477-B | Granulin precursor modulators and methods of use thereof | 阿库达医疗公司 | 2024-07-05 | — | — | CN | disclosed |
| US-20220251084-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | JANSSEN PHARMACEUTICA NV (BE) | 2022-08-11 | — | — | US | disclosed |
| EP-3983401-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | Arkuda Therapeutics (US) | 2022-04-20 | — | — | EP | disclosed |
| WO-2020252222-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | ARKUDA THERAPEUTICS (US) | 2020-12-17 | — | — | WO | disclosed |
| WO-2020252222-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | ARKUDA THERAPEUTICS (US) | 2020-12-17 | — | — | WO | disclosed |
| EP-2222160-A2 | HALOALLYLAMINE INHIBITORS OF SSAO/VAP-1 AND USES THEREFOR | Pharmaxis Ltd. (AU) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009066152-A2 | HALOALLYLAMINE INHIBITORS OF SSAO/VAP-1 AND USES THEREFOR | PHARMAXIS LTD. (US) | 2009-05-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220251084-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | GRN, PRNP, PSEN2 | HDAC2 2859/4885HDAC8 2108/4885HDAC6 800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.