Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 8/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.38 |
| ▸ | MEN1 | O00255 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 4/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2912520 | 0.86 | LCK (0.46) | MAPTKMT2AMEN1ALDH1A1HTT | |
| SCHEMBL2921480 | 0.85 | MAPT (0.42) | MAPTKMT2AMEN1ALDH1A1HTT | |
| SCHEMBL4526575 | 0.81 | AGTR2 (0.46) | PDE4APDE4BKMT2AMEN1TP53 | |
| SCHEMBL2918739 | 0.80 | KMT2A (0.40) | PDE4APDE4BMAPTKMT2AMEN1 | |
| SCHEMBL2923527 | 0.79 | MAPT (0.44) | MAPTKMT2AMEN1ALDH1A1TP53 | |
| SCHEMBL2920980 | 0.79 | MAPT (0.40) | MAPTKMT2AMEN1ALDH1A1TP53 | |
| SCHEMBL2915053 | 0.75 | MAPT (0.41) | MAPTKMT2AMEN1ALDH1A1HTT | |
| SCHEMBL7440230 | 0.73 | PDE4A (0.71) | PDE4APDE4BMAPTHTTNPC1 | |
| SCHEMBL2919335 | 0.72 | LCK (0.49) | MAPTLCK | |
| SCHEMBL2921874 | 0.72 | MAPT (0.42) | MAPTKMT2AMEN1ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225216-A1 | SUBSTITUTED BENZOAZOLE PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS | Decode Genetics EHF (IS) | 2010-09-08 | — | — | EP | disclosed |
| EP-2225215-A1 | SUBSTITUTED BENZOAZOLE PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS | Decode Genetics EHF (IS) | 2010-09-08 | — | — | EP | disclosed |
| WO-2009067604-A1 | SUBSTITUTED BENZOAZOLE PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |
| WO-2009067618-A1 | SUBSTITUTED BENZOAZOLE PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |