Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tezosentan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA known ✓ | P25101 | 20/20 | 0.99 |
| ▸ | EDNRB known ✓ | P24530 | 19/20 | 0.99 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tezosentan SCHEMBL387773 | 1.00 | EDNRA (0.99) | EDNRAEDNRB | |
| Tezosentan SCHEMBL4525 | 0.99 | EDNRA (1.00) | EDNRAEDNRB | |
| Clazosentan SCHEMBL29565931 | 0.91 | EDNRA (1.00) | EDNRAEDNRB | |
| Clazosentan SCHEMBL29706388 | 0.91 | EDNRA (1.00) | EDNRAEDNRB | |
| Clazosentan SCHEMBL1652657 | 0.91 | EDNRA (1.00) | EDNRAEDNRB | |
| Tezosentan SCHEMBL387772 | 0.89 | EDNRA (0.79) | EDNRAEDNRB | |
| Tezosentan SCHEMBL1230886 | 0.89 | EDNRA (0.79) | EDNRAEDNRB | |
| Tezosentan SCHEMBL4524 | 0.88 | EDNRA (0.80) | EDNRAEDNRB | |
| Tezosentan SCHEMBL29409604 | 0.88 | EDNRA (0.80) | EDNRAEDNRB | |
| Tezosentan SCHEMBL6963555 | 0.88 | EDNRA (0.79) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117957228-A | SGC stimulators | 帝善多制药公司 | 2024-04-30 | — | — | CN | disclosed |
| CN-117915917-A | CNS disease treatment using sGC stimulators | 帝善多制药公司 | 2024-04-19 | — | — | CN | disclosed |