⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11435656 | 0.73 | — | — | |
| SCHEMBL10962897 | 0.67 | — | — | |
| SCHEMBL10688375 | 0.67 | — | — | |
| SCHEMBL2565 | 0.67 | — | — | |
| SCHEMBL11421568 | 0.67 | — | — | |
| SCHEMBL5360418 | 0.67 | — | — | |
| SCHEMBL3661688 | 0.65 | — | — | |
| SCHEMBL16084768 | 0.65 | — | — | |
| SCHEMBL3763612 | 0.65 | — | — | |
| SCHEMBL10546124 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8883833-B2 | Substituted benzoazole PDE4 inhibitors for treating inflammatory, cardiovascular and CNS disorders | DECODE GENETICS EHF (IS) | 2014-11-11 | — | — | US | disclosed |
| US-8877816-B2 | 4-(or 5-) substituted catechol derivatives | DECODE GENETICS EHF (IS) | 2014-11-04 | — | — | US | disclosed |
| US-20140301999-A1 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS | DECODE GENETICS EHF (IS) | 2014-10-09 | — | — | US | disclosed |
| CN-101918380-B | Substituted benzoazole PDE4 inhibitors for treating inflammatory, cardiovascular and cns disorders | DECODE GENETICS EHF | 2014-09-24 | — | — | CN | disclosed |
| US-20140275553-A1 | SUBSTITUTED BENZOAZOLE PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS | DECODE GENETICS EHF (IS) | 2014-09-18 | — | — | US | disclosed |
| US-8791267-B2 | Biaryl PDE4 inhibitors for treating inflammatory, cardiovascular and CNS disorders | DECODE GENETICS EHF (IS) | 2014-07-29 | — | — | US | disclosed |
| EP-2674417-A2 | Biaryl PDE4 inhibitors for treating inflammation | Decode Genetics EHF (IS) | 2013-12-18 | — | — | EP | disclosed |
| CN-103351390-A | Biaryl pde4 inhibitors for treating pulmonary and cardiovascular disorders | DECODE GENETICS EHF | 2013-10-16 | — | — | CN | disclosed |
| EP-2628727-A2 | Biaryl PDE4 inhibitors for treating pulmonary and cardiovascular disorders | Decode Genetics EHF (IS) | 2013-08-21 | — | — | EP | disclosed |
| CN-102026970-B | Biaryl PDE4 inhibitors for the treatment of pulmonary and cardiovascular disorders | DECODE GENETICS EHF | 2013-07-31 | — | — | CN | disclosed |
| EP-0577065-B1 | Silicone surfactants having T-butyl terminated polyether pendants for use in high resilience polyurethane foam | OSI SPECIALTIES INC (US) | 1997-01-29 | — | — | EP | disclosed |
| EP-0254890-B1 | Polyether silicone copolymers with mixed hydroxy alkoxy capping for stabilizing high solid content, molded, flexible urethane foam | OSI SPECIALTIES INC (US) | 1995-03-08 | — | — | EP | disclosed |
| EP-0310929-B1 | Polyether silicone copolymers with secondary or tertiary hydroxy terminated for stabilizing high resiliency urethane foam | UNION CARBIDE CORP (US) | 1994-07-27 | — | — | EP | disclosed |
| EP-0577065-A1 | Silicone surfactants having T-butyl terminated polyether pendants for use in high resilience polyurethane foam | OSi Specialties, Inc. (US) | 1994-01-05 | — | — | EP | disclosed |
| US-5198474-A | Silicone surfactants having t-butyl terminated polyether pendants for use in high resilience polyurethane foam | UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) | 1993-03-30 | — | — | US | disclosed |
| EP-0310929-A2 | Polyether silicone copolymers with secondary or tertiary hydroxy terminated for stabilizing high resiliency urethane foam | OSi SPECIALTIES, INC. (US) | 1989-04-12 | — | — | EP | disclosed |
| US-4769174-A | NONIONIC SURFACTANTS; BREATHABILITY | UNION CARBIDE CORPORATION (US) | 1988-09-06 | — | — | US | disclosed |
| US-4746683-A | SURFACTANTS | UNION CARBIDE CORPORATION (US) | 1988-05-24 | — | — | US | disclosed |
| EP-0254890-A2 | Polyether silicone copolymers with mixed hydroxy alkoxy capping for stabilizing high solid content, molded, flexible urethane foam | OSi Specialties, Inc. (US) | 1988-02-03 | — | — | EP | disclosed |
| US-4690955-A | HIGH-BREATHABILITY OPEN-CELL FOAMS | UNION CARBIDE CORPORATION (US) | 1987-09-01 | — | — | US | disclosed |