Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 4/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 6/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2109763 | 0.76 | PRSS1 (0.66) | PRSS1PRSS2PRSS3MEN1KMT2A | |
| SCHEMBL1992570 | 0.69 | EDNRA (0.34) | PRSS1PRSS2PRSS3 | |
| SCHEMBL2110141 | 0.67 | PRSS1 (0.65) | PRSS1PRSS2PRSS3MAPTALDH1A1 | |
| SCHEMBL3438836 | 0.64 | SMN1; SMN2 (0.54) | PRSS1PRSS2PRSS3ALDH1A1HTT | |
| SCHEMBL15772000 | 0.64 | PRSS1 (0.32) | PRSS1PRSS2PRSS3 | |
| SCHEMBL2110266 | 0.64 | PRSS1 (0.58) | PRSS1PRSS2PRSS3 | |
| SCHEMBL2109922 | 0.64 | PRSS1 (0.62) | PRSS1PRSS2PRSS3NPC1RAB9A | |
| SCHEMBL2109420 | 0.63 | PRSS1 (0.80) | PRSS1PRSS2PRSS3 | |
| SCHEMBL2109470 | 0.62 | PRSS1 (0.70) | PRSS1PRSS2PRSS3NPC1RAB9A | |
| SCHEMBL2111845 | 0.62 | PRSS1 (0.64) | PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2224803-A1 | SPIROPIPERIDINES FOR USE AS TRYPTASE INHIBITORS | Janssen Pharmaceutica N.V. (BE) | 2010-09-08 | — | — | EP | disclosed |
| WO-2009067202-A1 | SPIROPIPERIDINES FOR USE AS TRYPTASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-05-28 | — | — | WO | disclosed |