SCHEMBL291967

SCHEMBL291967

O=C1NC(=O)C(Cc2ccc(OCCn3ccc4ccccc43)cc2)S1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 12/20 1.00
PPARG P37231 9/20 1.00
HRH3 Q9Y5N1 1/20 0.55
PPARA Q07869 6/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29547028 1.00 FFAR1 (1.00) FFAR1PPARGHRH3PPARA
SCHEMBL7835250 0.85 PPARG (0.73) FFAR1PPARGHRH3PPARA
SCHEMBL23465376 0.81 FFAR1 (0.69) FFAR1PPARGHRH3PPARA
SCHEMBL6508034 0.81 FFAR1 (0.68) FFAR1PPARGPPARA
SCHEMBL1072226 0.79 FFAR1 (0.77) FFAR1PPARGHRH3PPARA
SCHEMBL9143087 0.78 FFAR1 (0.64) FFAR1PPARGHRH3PPARA
SCHEMBL8128813 0.77 PPARG (0.63) FFAR1PPARGHRH3PPARA
SCHEMBL7512050 0.77 FFAR1 (0.63) FFAR1PPARGPPARA
SCHEMBL9570670 0.77 FFAR1 (0.71) FFAR1PPARGHRH3PPARA
SCHEMBL7837259 0.77 FFAR1 (0.63) FFAR1PPARGHRH3PPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 460 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1931350-B2 ADMINISTRATION OF DIPEPTIDYL PEPTIDASE INHIBITORS TAKEDA PHARMACEUTICALS CO (JP) 2021-08-04 EP claimed
EP-1942898-B2 DIPEPTIDYL PEPTIDASE INHIBITORS FOR TREATING DIABETES TAKEDA PHARMACEUTICAL (JP) 2014-05-14 EP claimed
EP-1931350-B1 ADMINISTRATION OF DIPEPTIDYL PEPTIDASE INHIBITORS TAKEDA PHARMACEUTICAL (JP) 2013-11-20 EP claimed
US-8338480-B2 Combination treatment of metabolic disorders WELLSTAT THERAPEUTICS CORPORATION (US) 2012-12-25 US claimed
EP-1942898-B1 DIPEPTIDYL PEPTIDASE INHIBITORS FOR TREATING DIABETES TAKEDA PHARMACEUTICAL (JP) 2011-11-09 EP claimed
US-20110212982-A1 Administration of Dipeptidyl Peptidase Inhibitors TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-09-01 US claimed
US-20110192748-A1 Administration of Dipeptidyl Peptidase Inhibitors TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-08-11 US claimed
US-20100292277-A1 COMBINATION TREATMENT OF METABOLIC DISORDERS WELLSTAT THERAPEUTICS CORPORATION (US) 2010-11-18 US claimed
EP-1942898-A1 DIPEPTIDYL PEPTIDASE INHIBITORS FOR TREATING DIABETES Takeda Pharmaceutical Company Limited (JP) 2008-07-16 EP claimed
EP-1931350-A2 ADMINISTRATION OF DIPEPTIDYL PEPTIDASE INHIBITORS Takeda Pharmaceutical Company Limited (JP) 2008-06-18 EP claimed
WO-2007033266-A2 DIPEPTIDYL PEPTIDASE INHIBITORS FOR TREATING DIABETIS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-03-22 WO claimed
WO-2007033350-A1 DIPEPTIDYL PEPTIDASE INHIBITORS FOR TREATING DIABETES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-03-22 WO claimed
US-20070060529-A1 ADMINISTRATION OF DIPEPTIDYL PEPTIDASE INHIBITORS DEVELOPMENT PARTNERS, LLC 2007-03-15 US claimed
US-20070060530-A1 ADMINISTRATION OF DIPEPTIDYL PEPTIDASE INHIBITORS TAKEDA SAN DIEGO, INC. 2007-03-15 US claimed
US-12209144-B2 Cyclic peptides as proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors for the treatment of metabolic disorders NOVARTIS AG (CH) 2025-01-28 US disclosed
US-20240036046-A1 CANCER EXAMINATION METHOD AND CANCER TREATMENT AGENT IMAMITSUKAI MEDICAL CORPORATION (JP) 2024-02-01 US disclosed
US-11813306-B2 Cyclic tetramer compounds as proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors for the treatment of metabolic disorders NOVARTIS AG (CH) 2023-11-14 US disclosed
US-5977365-A HYPOGLYCEMIC AGENTS SANKYO COMPANY, LIMITED (JP) 1999-11-02 US disclosed
US-5624935-A ANTIDIABETIC AGENTS, HYPOGLYCEMIC AGENTS OR ANTILIPEMIC AGENTS SANKYO COMPANY, LIMITED 1997-04-29 US disclosed
EP-0676398-A2 Heterocyclic compounds having anti-diabetic activity, their preparation and their use SANKYO COMPANY LIMITED (JP) 1995-10-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110192748-A1 Administration of Dipeptidyl Peptidase Inhibitors DPP4, DPP7, DPP3 FFAR1 1719/4885PPARG 2134/4885HRH3 3067/4885
US-11813306-B2 Cyclic tetramer compounds as proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors for the treatment of metabolic disorders PCSK9, PCSK7, PCSK6 FFAR1 256/4885PPARG 3245/4885HRH3 2147/4885
US-20100292277-A1 COMBINATION TREATMENT OF METABOLIC DISORDERS NR1H3, GPR119, NR1H2 FFAR1 6/4885PPARG 12/4885HRH3 293/4885
US-20070060530-A1 ADMINISTRATION OF DIPEPTIDYL PEPTIDASE INHIBITORS DPP4, DPP7, DPP3 FFAR1 1719/4885PPARG 2134/4885HRH3 3067/4885
US-20110212982-A1 Administration of Dipeptidyl Peptidase Inhibitors DPP4, DPP7, DPP3 FFAR1 2426/4885PPARG 2282/4885HRH3 2934/4885
US-12209144-B2 Cyclic peptides as proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors for the treatment of metabolic disorders PCSK9, PCSK7, PCSK6 FFAR1 1045/4885PPARG 3421/4885HRH3 1895/4885
US-20070060529-A1 ADMINISTRATION OF DIPEPTIDYL PEPTIDASE INHIBITORS DPP7, DPP4, DPP3 FFAR1 1866/4885PPARG 1967/4885HRH3 3326/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.