Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.35 |
| ▸ | CA2 | P00918 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL140011 | 0.80 | CA1 (0.37) | CA1CA2MEN1KMT2ACYP1A2 | |
| SCHEMBL12930022 | 0.76 | CYP2C9 (0.43) | CA1CA2MEN1KMT2ACYP1A2 | |
| SCHEMBL11998814 | 0.76 | CA1 (0.34) | CA1CA2MEN1KMT2ACYP1A2 | |
| SCHEMBL28924190 | 0.76 | MEN1 (0.36) | CA1CA2MEN1KMT2ACYP1A2 | |
| SCHEMBL18806835 | 0.75 | CA1 (0.37) | CA1CA2MEN1KMT2ACYP1A2 | |
| SCHEMBL18802300 | 0.75 | CA1 (0.37) | CA1CA2MEN1KMT2ACYP1A2 | |
| SCHEMBL409808 | 0.74 | CA1 (0.41) | CA1CA2MEN1KMT2ACYP1A2 | |
| SCHEMBL28599216 | 0.74 | MEN1 (0.37) | CA1CA2MEN1KMT2ACYP1A2 | |
| SCHEMBL1332907 | 0.73 | HTR2A (0.37) | CA1CA2MEN1KMT2ACYP1A2 | |
| SCHEMBL10227709 | 0.71 | CCNA2 (0.40) | CA1CA2MEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118206566-A | Hydroxypyridooxazepine as NRF2 activator | 葛兰素史密斯克莱知识产权发展有限公司 | 2024-06-18 | — | — | CN | disclosed |
| CN-113474349-B | Hydroxypyridooxazepine as NRF2 activator | 葛兰素史密斯克莱知识产权发展有限公司 | 2024-03-01 | — | — | CN | disclosed |