Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | MAP3K12 | Q12852 | 4/20 | 0.32 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.32 |
| ▸ | PDE4A | P27815 | 2/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | LPL | P06858 | 1/20 | 0.31 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.31 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24894999 | 1.00 | LRRK2 (0.35) | LRRK2USP30MAP3K12AOC3HRH3 | |
| SCHEMBL31153309 | 1.00 | LRRK2 (0.35) | LRRK2USP30MAP3K12AOC3HRH3 | |
| SCHEMBL24894892 | 0.93 | USP30 (0.36) | USP30MAP3K12AOC3PDE10AFFAR1 | |
| SCHEMBL29197236 | 0.93 | USP30 (0.36) | USP30MAP3K12AOC3PDE10AFFAR1 | |
| SCHEMBL23759883 | 0.93 | USP30 (0.36) | USP30MAP3K12AOC3PDE10AFFAR1 | |
| SCHEMBL30018701 | 0.86 | ADRA1A (0.37) | LRRK2USP30 | |
| SCHEMBL24894860 | 0.85 | USP30 (0.35) | LRRK2USP30MAP3K12AOC3FFAR1 | |
| SCHEMBL31217296 | 0.85 | HDAC6 (0.40) | LRRK2USP30AOC3FFAR1DGAT2 | |
| SCHEMBL23797377 | 0.82 | FFAR1 (0.37) | USP30FFAR1LPLLIPG | |
| SCHEMBL2188747 | 0.82 | FFAR1 (0.37) | USP30FFAR1LPLLIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117940435-A | Novel compounds for diagnosing TDP-43 proteinopathies | AC免疫有限公司 | 2024-04-26 | — | — | CN | disclosed |
| WO-2023285661-A1 | NOVEL COMPOUNDS FOR THE DIAGNOSIS OF TDP-43 PROTEINOPATHIES | AC IMMUNE SA (CH) | 2023-01-19 | — | — | WO | disclosed |