Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 4/20 | 0.40 |
| ▸ | CKS1B | P61024 | 2/20 | 0.38 |
| ▸ | SKP1 | P63208 | 2/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30112336 | 1.00 | AAK1 (0.43) | AAK1PDE10ARETCKS1BSKP1 | |
| SCHEMBL24873015 | 0.91 | PDE10A (0.40) | AAK1PDE10APRMT5CHRM4PIK3CD | |
| SCHEMBL25074365 | 0.87 | RET (0.40) | RETCKS1BSKP1SKP2PRMT5 | |
| SCHEMBL24873234 | 0.87 | PIK3CD (0.39) | AAK1PDE10APRMT5PIK3CDGPR119 | |
| SCHEMBL30112427 | 0.87 | PIK3CD (0.39) | AAK1PDE10APRMT5PIK3CDGPR119 | |
| SCHEMBL24670866 | 0.86 | CKS1B (0.42) | RETCKS1BSKP1SKP2PRMT5 | |
| SCHEMBL30888783 | 0.86 | CKS1B (0.42) | RETCKS1BSKP1SKP2PRMT5 | |
| SCHEMBL29990537 | 0.86 | GPR119 (0.42) | CKS1BSKP1SKP2PRMT5PIK3CD | |
| SCHEMBL24670657 | 0.86 | GPR119 (0.42) | CKS1BSKP1SKP2PRMT5PIK3CD | |
| SCHEMBL30661508 | 0.84 | AAK1 (0.38) | AAK1PDE10ARETCKS1BSKP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117940414-A | Compounds for targeting IRAK4 protein degradation | 渤健马萨诸塞州股份有限公司 | 2024-04-26 | — | — | CN | disclosed |