Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | PRKDC | P78527 | 7/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | LGMN | Q99538 | 1/20 | 0.32 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29925901 | 0.87 | KDM4E (0.37) | KDM4EPRKDCMAPTMEN1ALOX15 | |
| SCHEMBL27032428 | 0.87 | KDM4E (0.37) | KDM4EPRKDCMAPTMEN1ALOX15 | |
| SCHEMBL25717573 | 0.85 | KDM4E (0.35) | KDM4EPRKDCMAPTMEN1ALOX15 | |
| SCHEMBL27032333 | 0.84 | KDM4E (0.39) | KDM4EPRKDCMAPTMEN1ALOX15 | |
| SCHEMBL29925545 | 0.84 | KDM4E (0.39) | KDM4EPRKDCMAPTMEN1ALOX15 | |
| SCHEMBL27574767 | 0.72 | KDM4E (0.50) | KDM4EPRKDCMAPTMEN1ALOX15 | |
| SCHEMBL5443641 | 0.72 | KDM4E (0.50) | KDM4EPRKDCMAPTMEN1ALOX15 | |
| SCHEMBL16795129 | 0.70 | MAOB (0.36) | KDM4EMAPTKMT2AESR1ESR2 | |
| SCHEMBL24269757 | 0.68 | KDM4E (0.35) | KDM4EPRKDCMAPTMEN1ALOX15 | |
| SCHEMBL9232165 | 0.68 | LMNA (0.57) | KDM4EPRKDCMAPTMEN1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117425661-A | Macrocyclic LRRK2 kinase inhibitors | 法国施维雅药厂 | 2024-01-19 | — | — | CN | disclosed |