Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 11/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.49 |
| ▸ | GBA1 | P04062 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2919874 | 1.00 | CYP3A4 (0.53) | CYP3A4ALDH1A1KDM4EKMT2AFKBP1A | |
| SCHEMBL2919878 | 1.00 | CYP3A4 (0.53) | CYP3A4ALDH1A1KDM4EKMT2AFKBP1A | |
| SCHEMBL19408855 | 0.88 | CYP3A4 (0.50) | CYP3A4ALDH1A1KDM4EKMT2AFKBP1A | |
| SCHEMBL5368566 | 0.88 | CYP3A4 (0.50) | CYP3A4ALDH1A1KDM4EKMT2AFKBP1A | |
| SCHEMBL1440329 | 0.88 | CYP3A4 (0.50) | CYP3A4ALDH1A1KDM4EKMT2AFKBP1A | |
| SCHEMBL24938939 | 0.88 | CYP3A4 (0.50) | CYP3A4ALDH1A1KDM4EKMT2AFKBP1A | |
| SCHEMBL4249938 | 0.88 | CYP3A4 (0.50) | CYP3A4ALDH1A1KDM4EKMT2AFKBP1A | |
| SCHEMBL15325590 | 0.88 | CYP3A4 (0.50) | CYP3A4ALDH1A1KDM4EKMT2AFKBP1A | |
| SCHEMBL2818883 | 0.88 | CYP3A4 (0.50) | CYP3A4ALDH1A1KDM4EKMT2AFKBP1A | |
| SCHEMBL2768950 | 0.88 | FKBP1A (0.54) | CYP3A4ALDH1A1KDM4EKMT2AFKBP1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010506-B1 | DIAZEPAN DERIVATIVES MODULATORS OF CHEMOKINE RECEPTORS | HOFFMANN LA ROCHE (CH) | 2010-08-04 | — | — | EP | disclosed |
| US-7632829-B2 | Diazepan derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-12-15 | — | — | US | disclosed |
| EP-2010506-A1 | DIAZEPAN DERIVATIVES MODULATORS OF CHEMOKINE RECEPTORS | F. Hoffmann-Roche AG (CH) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007122103-A1 | DIAZEPAN DERIVATIVES MODULATORS OF CHEMOKINE RECEPTORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-11-01 | — | — | WO | disclosed |
| US-20070249589-A1 | Novel diazepan derivatives | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2007-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249589-A1 | Novel diazepan derivatives | CCR3, CCR1, CCR10 | CYP3A4 1507/4885ALDH1A1 2871/4885KDM4E 3080/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.