Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5742209 | 0.83 | SMN1; SMN2 (0.57) | ATMKCNH2KDM4EALDH1A1MEN1 | |
| SCHEMBL5742201 | 0.83 | SMN1; SMN2 (0.57) | ATMKCNH2KDM4EALDH1A1MEN1 | |
| SCHEMBL22360604 | 0.78 | CYP2D6 (0.56) | CYP2D6CYP2C9CYP3A4CYP2C19ATM | |
| SCHEMBL14052244 | 0.77 | ACHE (0.57) | CYP2D6CYP2C9TSHR | |
| SCHEMBL10856233 | 0.77 | CHRM2 (0.67) | CYP2D6ATMHDAC4KCNH2HDAC1 | |
| SCHEMBL10313031 | 0.77 | CYP2D6 (0.55) | CYP2D6CYP2C9CYP3A4CYP2C19ATM | |
| SCHEMBL24672242 | 0.77 | KDM4E (0.68) | ATMKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL1394539 | 0.77 | KDM4E (0.68) | ATMKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL21797152 | 0.77 | KDM4E (0.68) | ATMKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL1394535 | 0.77 | KDM4E (0.68) | ATMKDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4631942-A1 | PAN-KRAS DEGRADING AGENT, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Leadingtac Pharmaceutical (Shaoxing) Co., Ltd. (CN) | 2025-10-15 | — | — | EP | disclosed |
| EP-4606803-A1 | KRAS G12D DEGRADATION AGENT, AND PREPARATION METHOD AND USE THEREFOR | Leadingtac Pharmaceutical (Shaoxing) Co., Ltd. (CN) | 2025-08-27 | — | — | EP | disclosed |
| CN-117917410-A | Pan-KRAS degradation agent and preparation method and application thereof | 上海领泰生物医药科技有限公司 | 2024-04-23 | — | — | CN | disclosed |
| CN-117917416-A | KRAS G12D degradation agent and preparation method and application thereof | 上海领泰生物医药科技有限公司 | 2024-04-23 | — | — | CN | disclosed |