Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.56 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.54 |
| ▸ | MC4R | P32245 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | IGF1R | P08069 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29201752 | 1.00 | KDM4E (0.56) | KDM4ESIGMAR1APOBEC3ARECQLAPOBEC3G | |
| SCHEMBL30816869 | 0.84 | SIGMAR1 (0.60) | KDM4ESIGMAR1APOBEC3ARECQLAPOBEC3G | |
| SCHEMBL30816895 | 0.84 | SIGMAR1 (0.60) | KDM4ESIGMAR1APOBEC3ARECQLAPOBEC3G | |
| SCHEMBL30864070 | 0.84 | SIGMAR1 (0.60) | KDM4ESIGMAR1APOBEC3ARECQLAPOBEC3G | |
| SCHEMBL21164624 | 0.81 | KDM4E (0.64) | KDM4ESIGMAR1APOBEC3ARECQLAPOBEC3G | |
| SCHEMBL3312142 | 0.81 | KMT2A (0.69) | KDM4ESIGMAR1APOBEC3ARECQLAPOBEC3G | |
| SCHEMBL24672242 | 0.80 | KDM4E (0.68) | KDM4ESIGMAR1MC4RLMNAPOLB | |
| SCHEMBL1394539 | 0.80 | KDM4E (0.68) | KDM4ESIGMAR1MC4RLMNAPOLB | |
| SCHEMBL21797152 | 0.80 | KDM4E (0.68) | KDM4ESIGMAR1MC4RLMNAPOLB | |
| SCHEMBL1394535 | 0.80 | KDM4E (0.68) | KDM4ESIGMAR1MC4RLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117917416-A | KRAS G12D degradation agent and preparation method and application thereof | 上海领泰生物医药科技有限公司 | 2024-04-23 | — | — | CN | disclosed |