Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
| ▸ | PRKDC | P78527 | 1/20 | 0.49 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30770636 | 1.00 | PIK3CA (0.50) | PIK3CAPIK3CBMTORPRKDCPIK3C3 | |
| SCHEMBL30770752 | 0.92 | PIK3CA (0.60) | PIK3CAPIK3CBMTORPRKDCPIK3C3 | |
| SCHEMBL25682967 | 0.85 | PIK3CA (0.51) | PIK3CAPIK3CBMTORPRKDCPIK3C3 | |
| SCHEMBL31516558 | 0.82 | PIK3CA (0.61) | PIK3CAPIK3CBMTORPRKDCPIK3C3 | |
| SCHEMBL25682985 | 0.82 | PIK3CA (0.53) | PIK3CAPIK3CBMTORPRKDCPIK3C3 | |
| SCHEMBL25682965 | 0.81 | PIK3CA (0.58) | PIK3CAPIK3CBMTORPRKDCPIK3C3 | |
| SCHEMBL24679199 | 0.80 | PIK3CA (0.56) | PIK3CAPIK3CBMTORPRKDCPIK3C3 | |
| SCHEMBL25685461 | 0.79 | PIK3CA (0.69) | PIK3CAPIK3CBMTORPRKDCPIK3C3 | |
| SCHEMBL25682966 | 0.79 | PIK3CA (0.55) | PIK3CAPIK3CBMTORPRKDCPIK3C3 | |
| SCHEMBL25683181 | 0.78 | PIK3CA (0.54) | PIK3CAPIK3CBMTORPRKDCPIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4347040-A1 | ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF CANCER | Petra Pharma Corporation (US) | 2024-04-10 | — | — | EP | disclosed |
| CN-117769546-A | Allosteric ketene inhibitors of phosphoinositide 3-kinase (PI 3K) for the treatment of disease | 佩特拉制药公司 | 2024-03-26 | — | — | CN | disclosed |