Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.52 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | STAT1 | P42224 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | PDE5A | O76074 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11685844 | 0.86 | CYP1A2 (0.65) | KDM4EALDH1A1EGFRSMN1; SMN2HTT | |
| SCHEMBL11846406 | 0.81 | KDM4E (0.63) | KDM4EALDH1A1HPGDSMN1; SMN2HTT | |
| SCHEMBL11090480 | 0.79 | KDM4E (0.66) | KDM4EALDH1A1EGFRLMNAMEN1 | |
| SCHEMBL29205296 | 0.79 | EGFR (0.52) | EGFRHTTMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11087390 | 0.78 | KDM4E (0.64) | KDM4EALDH1A1EGFRLMNAMEN1 | |
| SCHEMBL11084344 | 0.77 | EGFR (0.70) | KDM4EALDH1A1HPGDEGFRHTT | |
| SCHEMBL4351924 | 0.77 | RAF1 (0.56) | KDM4EALDH1A1EGFRHTTLMNA | |
| SCHEMBL11849897 | 0.77 | HDAC1 (0.60) | KDM4EALDH1A1HPGDSMN1; SMN2HTT | |
| SCHEMBL11855329 | 0.77 | HDAC1 (0.60) | KDM4EALDH1A1HPGDSMN1; SMN2HTT | |
| SCHEMBL11857739 | 0.77 | HDAC1 (0.60) | KDM4EALDH1A1HPGDSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4398902-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING INHIBITORS OF AMYLOID PEPTIDE INTERACTIONS WITH GLYCOSAMINOGLYCANS, METHODS OF TREATMENT, AND USE THEREOF | Gismo Therapeutics, Inc. (US) | 2024-07-17 | — | — | EP | disclosed |
| CN-117999075-A | Compounds and pharmaceutical compositions comprising inhibitors of amyloid peptide interaction with glycosaminoglycans, methods of treatment, and uses thereof | 吉斯莫治疗股份有限公司 | 2024-05-07 | — | — | CN | disclosed |
| WO-2023038876-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING INHIBITORS OF AMYLOID PEPTIDE INTERACTIONS WITH GLYCOSAMINOGLYCANS, METHODS OF TREATMENT, AND USE THEREOF | GISMO THERAPEUTICS, INC. (US) | 2023-03-16 | — | — | WO | disclosed |