Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2926843 | 0.92 | SMN1; SMN2 (0.47) | SMN1; SMN2MEN1KMT2ACYP2C19MAPT | |
| SCHEMBL2923195 | 0.92 | SMN1; SMN2 (0.45) | SMN1; SMN2MEN1KMT2ACYP2C19MAPT | |
| SCHEMBL2921535 | 0.92 | SMN1; SMN2 (0.48) | SMN1; SMN2MEN1KMT2ACYP2C19MAPT | |
| SCHEMBL2929524 | 0.91 | SMN1; SMN2 (0.47) | SMN1; SMN2MEN1KMT2ACYP2C19MAPT | |
| SCHEMBL2927272 | 0.89 | SMN1; SMN2 (0.45) | SMN1; SMN2MEN1KMT2ACYP2C19MAPT | |
| SCHEMBL2928406 | 0.86 | SMN1; SMN2 (0.43) | SMN1; SMN2MEN1KMT2ACYP2C19MTOR | |
| SCHEMBL18484168 | 0.84 | HDAC1 (0.41) | SMN1; SMN2MEN1KMT2ACYP2C19MAPT | |
| SCHEMBL2926897 | 0.83 | AURKA (0.53) | SMN1; SMN2MEN1KMT2AMAPTLMNA | |
| SCHEMBL2927297 | 0.82 | AURKA (0.56) | MEN1KMT2ALMNANPC1TP53 | |
| SCHEMBL1891508 | 0.80 | MTOR (0.40) | MEN1KMT2ACYP2C19MTORMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644376-B1 | PYRROLO 3,4-c PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2010-09-08 | — | — | EP | disclosed |
| US-7582628-B2 | Pyrrolo[3,4-c]pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-09-01 | — | — | US | disclosed |
| US-20060276471-A1 | Pyrrolo[3,4-c]pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (FORMERLY PHARMACIA ITALIA S.P.A.) (IT) | 2006-12-07 | — | — | US | disclosed |
| EP-1644376-A1 | PYRROLO 3,4-c PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005005427-A1 | PYRROLO[3,4-c]PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2005-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276471-A1 | Pyrrolo[3,4-c]pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K3, MAP3K19, MAP3K9 | SMN1; SMN2 4283/4885MEN1 3542/4885KMT2A 1990/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.