Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.43 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.43 |
| ▸ | GRN | P28799 | 4/20 | 0.42 |
| ▸ | SORT1 | Q99523 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | VNN1 | O95497 | 2/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | GLS | O94925 | 1/20 | 0.35 |
| ▸ | WDR5 | P61964 | 1/20 | 0.34 |
| ▸ | PYGL | P06737 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30903295 | 1.00 | CD274 (0.43) | CD274PDCD1GRNSORT1TSHR | |
| SCHEMBL29213351 | 1.00 | CD274 (0.43) | CD274PDCD1GRNSORT1TSHR | |
| SCHEMBL29213347 | 0.85 | GRN (0.42) | CD274PDCD1GRNSORT1SIRT2 | |
| SCHEMBL29213352 | 0.85 | GRN (0.42) | CD274PDCD1GRNSORT1SIRT2 | |
| SCHEMBL30903298 | 0.82 | LMNA (0.47) | SMN1; SMN2CYP2C9 | |
| SCHEMBL29213277 | 0.82 | LMNA (0.47) | SMN1; SMN2CYP2C9 | |
| SCHEMBL29213281 | 0.82 | LMNA (0.47) | SMN1; SMN2CYP2C9 | |
| SCHEMBL29213380 | 0.82 | GRN (0.42) | CD274PDCD1GRNSORT1PYGL | |
| SCHEMBL29213377 | 0.82 | GRN (0.42) | CD274PDCD1GRNSORT1PYGL | |
| SCHEMBL31601087 | 0.80 | GRN (0.67) | CD274PDCD1GRNSORT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118019533-A | 2-Amino-5, 5-dimethylhexanoic acid derivatives as sortilin modulators for the treatment of central nervous system diseases | 因苏森斯有限公司 | 2024-05-10 | — | — | CN | claimed |
| CN-118019533-A | 2-Amino-5, 5-dimethylhexanoic acid derivatives as sortilin modulators for the treatment of central nervous system diseases | 因苏森斯有限公司 | 2024-05-10 | — | — | CN | disclosed |